Abstract
This paper reports on synthesis of hollow spheres of magnetite, guided by micelles and their application in drug release by the stimulus responsive technique. Here oleyelamine micelles are used as the core substance for the formation of magnetite nano hollow spheres (NHS). Diameter and shell thickness of NHS have been changed by changing concentration of the micelles. Mechanism of NHS formation has been established by investigating the aliquot collected at different time during the synthesis of NHS. It has been observed that oleyelamine as micelles play an important role to generate hollow-sphere particles of different diameter and thickness just by varying its amount. Structural analysis was done by XRD measurement and morphological measurements, SEM and TEM were performed to confirm the shape and size of the NHS. FTIR measurement support the formation of magnetite phase too. Frequency dependent AC magnetic measurements and AC magnetic field stimulated drug release event by these particles provide a direction of the promising application of these NHS for better cancer treatment in near future. Being hollow & porous in structure and magnetic in nature, such materials will also be useful in other applications such as in removal of toxic materials, magnetic separation etc.
Highlights
The synthesis procedure of the hollow spheres is as follows: Here three different sets of particles were prepared by varying the amount of oleylamine micelles. 2.4 gm of FeCl3, 6H2O was mixed in 40 ml Ethylene Glycol (EG) and 20 ml ethyl alcohol solution for all sets of particles
The selected area electron diffraction (SAED) pattern taken from the complete hollow sphere (Fig. 1(d)) exhibits the high crystalline nature of the Fe3O4 nano hollow spheres (NHS)
Magnetite hollow sphere particles have been prepared using oleylamine micelles using as core substance and varying the number of formation of micelles, size and shell thickness of the particles have been altered successfully
Summary
This paper reports on synthesis of hollow spheres of magnetite, guided by micelles and their application in drug release by the stimulus responsive technique. Magnetite nanoparticles are widely considered as a promising agent for the same due to its various advantageous features such as bio-safety, biocompatibility, ease of preparation and handling, low cost, stability and more importantly, possibility of carrying the drug to the desired location within the host body by using an external magnetic field In this way, proper delivery of drugs to selective region and magnetic field stimulated drug release may provide a new and effective pathway for treatment of cancer. A method has been described for synthesis of nano hollow sphere magnetite of different sizes by oleylamine micelles templated way By applying this oleylamine technique, many other kinds of ferrites can be synthesized. Before its practice it is necessary to be investigated systematically
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