Abstract
The mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by the aerosol-assisted method for loading and release of ibuprofen (IBU). The synthesized samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N2 adsorption–desorption isotherms. The drug IBU was applied as a model drug to investigate the drug release behaviour by ultraviolet spectrophotometry measurements. The investigation results demonstrate that mesoporous silicate molecular sieves by the aerosol-assisted method are spherical with a core–shell structure. As the drug carrier, it has good structural stability and can achieve drug controlled release which is expected. It exhibits safety to a certain degree. Therefore, the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers.
Highlights
In recent years, the research of drug-sustained-release preparations has been a hot topic in the medical community [1,2,3]
The morphology of most synthesized samples is spherical with a particle size of about 200 nm
After the loading process was completed, the sample was filtered by vacuum suction filtration, washed by ethanol and dried at room temperature to obtain a molecular sieve loaded with IBU
Summary
The research of drug-sustained-release preparations has been a hot topic in the medical community [1,2,3]. Mesoporous molecular sieve refers to a three-dimensional porous material with a pore size of 2–50 nm. The aerosol-assisted method shows its unique advantages in the synthesis of molecular sieves: (i) it is easy to control the composition of the product, the size and morphology of the particles; (ii) it has high atom utilization rate and high product yield; (iii) heteroatom distribution is more uniform; (iv) the synthesis process is fast and efficient, and it can effectively reduce water pollution; (v) the structure of the synthesized material is changeable and easy to control; and (vi) the aerosol process can obtain some metastable products, which can be used for products that are difficult to synthesize by water and heat [37,38,39,40,41,42]. It can quickly reach the adsorption equilibrium and have a significant slow-release effect during the drug loading process
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
