Synthesis of mesoporous alumina: an impact of surface chemistry on release behavior

Abstract

The present investigation describes the successful synthesis of mesoporous alumina (MeAl) nanoparticles for controlled drug delivery via a soft template route have been adopted using hexadecyltrimethyl ammonium bromide as template and aluminum chloride as precursor. The obtained Langmuir type II isotherm for MeAl showed P/Po 0.1 at 10 cm3/G STP. The Brunauer-Emmett-Teller study revealed the formation of uniform morphology and mesoporous structure. The fourier transform infrared spectroscopy study confirmed the presence of characteristic peaks of mesoporous alumina. Elemental analysis demonstrated the substantial Al and O peak supported with nanosized crumb with cluster by field emission scanning electron microscopy. The transmission electron microscopy indicates wormhole strikingly inter connected pore system assigned to functionalized MeAl. X-ray diffraction pattern suggests the formation of γ-Aluminum oxide. The particle size and surface charge of synthesized MeAl were successfully analyzed to assess the surface charge. The drug loading was confirmed by spectroscopic study with eloquent extension in drug release was found to be 74.44% attributed to release by control manner. In present study, synthesized MeAl holds an excellent compassionate impact on particle size and exterior chemistry for sustained release of model drug.