Synthesis of Magnetite Complexes with Drugs

Abstract

In recent years, there has been growing interest in magnetic substances for the creation of magnetic pharmaceutical preparations. In particular, it was reported that magnetite can be used as a drug carrier, which makes it possible to create magnetically guided drugs. Such drugs can be delivered to a target organ under the action of an external magnetic field [1]. There are three directions in the creation of magnetically guided drugs. The first solution is based on the use of binding agents such as dextran, dextrin, acrylic acid, etc. [2 – 5], whereby a polymeric coat is formed on the surface of a magnetic particle and then a drug is grafted to this coat [1, 6 – 8]. The second method consists in encapsulation of both a magnetic carrier and a drug in various shells such as ferritin, leukocytes, erythrocytes, or liposomes [9 – 12]. According to the third approach, a drug is grafted directly on the surface of a magnetic carrier without uses polymeric binders or encapsulating materials [13]. We believe that this approach is advantageous because it using simpler technology and equipment, provides higher production rates, and ensures better economic parameters. The third direction has still not been theoretically grounded and is insufficiently studied in its practical aspects. In this context, we have studied several complexes of the magnetite – drug type obtained by direct interaction of magnetite with various biologically active substances.