Abstract
Pyroglutamylhistidyltryptophyl-(O-Bzl) seryl-(O-Bzl) tyrosylglycylleucyl-(NG-nitro)-arginylprolylglycinamide was synthesized by successive fragment condensations of three peptide derivatives, pGlu-His-NHNH2, Boc-Trp-(O-Bzl) Ser-(O-Bzl) Tyr-Gly-NHNH2 and Boc-Leu-(NG-nitro) Arg-Pro-Gly-NH2 ; the latter two were prepared by the modified solid phase method using bromoacetylpolystyrene resin as carrier. Removal of all the protecting groups from the decapeptide derivative was easily effected by hydrogenolysis over a new type of catalyst, colloidal palladium on PVP. Thus the present reduction method made the large scale production of the peptide quite easy.
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