Abstract
Boc-Asp-Ot-Bu was efficiently converted to Boc-Abu(PO3Me2)-Ot-Bu in five steps then to Boc-Abu(PO3Me2)-OH in two steps. Both the protected amino acids were used in the syntheses of Boc-Leu-Abu(PO3Me2)-Ot-Bu and Boc-Glu(OBzl)-Abu(PO3Me2)-Leu-OBzl by the Boc mode of peptide synthesis. These were deprotected to Leu-Abu(P) and Glu-Abu(P)-Leu by hydrogenolysis followed by bromotimethylsilane treatment.
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