Abstract
meso-Lanthionine (Figure 1) is a monosulfide analogue of cystine that occurs in a family of polycyclic peptides with antibiotic properties called lantibiotics. So far only nisin has been made synthetically [1]. With their high specificity against Gram-positive bacteria [2], biological studies of these peptides are of interest, especially in the search for new groups of antibiotics. The aim of this project is to develop the foundation of the total solid phase synthesis of lantibiotics and their analogues by investigating the possibility of a rapid and high yielding method for synthesizing smaller lanthionine-containing peptides, solely on solid phase.
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