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Abstract
Organophosphorus derivatives of lactams attract attention as promising ligands and biologically active compounds [1]. In the present work we propose a convenient synthesis of amido(ethoxy)methylphosphonates I containing pyrrolidone and valeroand caprolactams fragments. Hence N-diethoxymethyllactams A react with diethyl trimethylsilyl and diethyl hydrogen phosphites at 130 150 C in the presence of zinc chloride to form phosphonates I. Using diethyl trimethylsilyl phosphite is optimal and provides high yields of phosphonates I, whereas with diethyl hydrogen phosphite, the yield is much lower.
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