Synthesis of Internal Alkynes through the Pd‐Catalyzed Coupling of Heteroaryl Halides with Terminal Alkynes

Abstract

AbstractSonogashira‐type cross‐couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature. The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds. The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct functionalization of heterocycles.