Abstract
AbstractAlkynes serve as prevalent intermediates in the synthesis of natural products and pharmaceuticals. We here described a new and efficient route to internal alkynes by Pd‐catalyzed Kumada cross‐coupling reactions of alkynyl halides with Grignard reagents. In the presence of Pd(PPh3)4 and N1,N1,N2,N2‐tetramethylethane‐1,2‐diamine (TMEDA), a variety of alkynyl halides underwent Kumada coupling with Grignard reagents, giving the corresponding internal alkynes in moderate to good yields.
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