Abstract
Methods Detection of H. pylori infection was performed by a 13C-urea breath test in 31 patients with UC. In each patient, a serum sample was drawn to measure IL-10 by the ELISA technique. Based on the primary breath test result, two groups were formed and serum IL-10 was measured. Results Serological IL-10 levels in patients with UC and negative 13C-urea breath test was 10.28 pg/ml whereas in patients with UC and positive 13C-urea breath test was 5.5 pg/ml (P = 0.035). IL-10 levels were higher in the inflammatory endoscopic and histological active groups which tested positive in the 13C-urea breath tests for H. pylori (P < 0.05).Conclusions The role of IL-10 secretion in patients with UC in determining the clinicopathological outcome of infection merits further study. This study suggests an association between serum IL-10 and disease severity in patients with UC and HP infection.
Highlights
Recent epidemiological evidence suggests an inverse relationship between Helicobacter pylori (HP) infection and inflammatory chronic diseases like asthma and eosinophilic esophagitis [1]
A study carried in Hungary with 133 patients with inflammatory bowel disease (IBD) and a similar control number found a significant inverse relationship with HP infection
The aim of this study was to determine the association of HP infection with the synthesis of Interleukin 10 (IL-10) in Mexican patients with ulcerative colitis (UC)
Summary
Recent epidemiological evidence suggests an inverse relationship between Helicobacter pylori (HP) infection and inflammatory chronic diseases like asthma and eosinophilic esophagitis [1]. A study carried in Hungary with 133 patients with IBD and a similar control number found a significant inverse relationship with HP infection. 13% of the patients with IBD were carriers of the infection whereas in the control group was between 39 and 67% [3]. Another meta-analysis reported that only 27% of patients with IBD had HP against 40% of individuals without the infection suggesting an inverse relationship between both entities [7]. An additional study performed in the US with 1000 IBD patients who had gastric biopsy confirmed an inverse relationship between the infection and IBD development [8]
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