Abstract
Dimethyl 3-(trifluoromethyl)indolizine-1,2-dicarboxylate (4), 1,2,3-tris(trifluoromethyl)indolizine (5), and ethyl trans -2,3-bis(trifluoromethyl)-2,3-dihydroindolizine-1-carboxylate (7) have been obtained via treatment of N-(2,2,2-trifluoroethyl)pyridinium triflate (2) with a base (B) and dimethyl acetylenedicarboxylate [→ 4 (B = Et 3N)] or perfluorobut-2-yne [→ 5 (B = K 2CO 3); → 7 (B = Et 3N)]. Correct elemental analyses [C,H,F and N except in the case of the triflate (2), where F was not determined] and spectroscopic data (i.r., n.m.r., mass) consistent with structures assigned were obtained for compounds 2, 4, 5 and 7. The structure of the dihydroindolizine (7) was established absolutely by X-ray crystallography, the analysis being carried out by Dr. R. G. Pritchard (UMIST), to whom we are extremely grateful. We are also indebted to the Iraqi Ministry of Higher Education and Science for the award of a Scholarship (to. S. N. M.).
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