Abstract
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a cardioprotective phytochemical occurring in many plant products. In this study, a new series of imine congeners of resveratrol has been synthesized in which the imine moiety replaced the double bond in the structure of resveratrol. In addition, the in vitro antiplatelet activity of these resveratrol derivatives has been evaluated against adenosine diphosphate (ADP), arachidonic acid (AA), and collagen as platelet aggregation inducers. In general, the synthesized compounds were active as antiplatelet agents, and, therefore, the imine functional group may be considered as an effective replacement for a double bond in resveratrol for developing new and promising antiplatelet drugs.
Highlights
Cardiovascular diseases (CVDs) are recognized as the first global cause of death
A structure of resveratrol of resveratrol in which the imine moiety replaced the double bond in the (Figure 1) [28], and the evaluation of their in vitro antiplatelet activity against adenosine diphosphate
The designed compounds were synthesized by the reaction of different aniline derivatives with appropriate aldehydes in water as a green solvent without any catalyst (Figure 2)
Summary
Cardiovascular diseases (CVDs) are recognized as the first global cause of death. It has been reported by the World Health Organization (WHO) that 17.7 million people died from CVDs in. Resveratrol (3,5,40 -trihydroxy-trans-stilbene) (1) (Figure 1) is one of these lead compounds. This stilbene is found in many natural sources such as grapes, Molbank 2019, 2019, M1039; doi:10.3390/M1039 www.mdpi.com/journal/molbank. 3-(phenylimino)indolin-2-one derivatives as antiplatelet agents [21]. Among their synthesized derivatives, compound (2) exhibited high antiplatelet activity against arachidonic acid (AA) as a platelet aggregation inducer (IC50 = 3.4 μM) [21]. Various biological of resveratrol these and reported derivatives remarkableactivities antiplatelet activity. Synthesized and of the present research was aimed at the synthesis of a new series of imine congeners evaluated the in antiplatelet ofthe resveratrol.
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