Abstract
A series of nine novel imidazo[1,2-a]pyridin-chromones and nine novel imidazo[1,2-a]pyridin-6-fluorochromones were synthesized in good to excellent yields by a MW assisted Groebke–Blackburn–Bienaymé reaction (GBB) under mild thermal and acidic conditions. Additionally, optimized geometries for the two non-prepared 5-bromoimidazo[1,2-a]pyridin-chromones were calculated at the TPSSh/6-311G(d) level of theory in order to understand the role of the steric strain in the GBB process.
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