Abstract
Abstract A convenient synthetic route to the iboga-scaffolds is described. Important steps include a Pd-catalyzed regiospecific indole formation between internal alkyne-substituted isoquinuclidine and 2-iodoaniline. The final cyclization was done using Trost’s Pd(II)–Ag(I) mixed-metal-mediated cyclization method originally developed for the synthesis of ibogamine. Both exo - (iboga) and endo -isomers (epi-iboga) at C-19 substitution with –CO 2 Me have been reported.
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