Abstract
A series of HIV vaccine models based on lactose-bound poly(lysine) scaffolds was synthesized. A spherical poly(lysine) dendrimer was prepared to bind lactose at the peripheral through reductive amination. Lactose-poly(lysine) dendrimers with the degree of substitution (DS) varying from 5 to 19 were obtained by controlling the feeding ratio of lactose to the poly(lysine) dendrimer. Three succinylated compounds such as succinyl monobenzylate, ethyl-phenylalanyl succinylamide and succinyl-L-alanyl-L-prolyl-L-alanine p-nitroanilide which were regarded as antigen peptide models were bound to the lactose-poly(lysine) dendrimer through esterification between the carboxyl group of the succinyl moiety and the 6-OH group of the lactose residue. The DS of resulting vaccine models was investigated by NMR spectra analyses.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
