Synthesis of Heterocylic Compounds of Biological Interest from Carbohydrate Derivatives

M F Martinez Esperón,N B D’Accorso,M L Fascio

doi:10.3390/50300418

Abstract

The synthesis of some isoxazolic compounds from carbohydrate derivatives is described. These products are obtained by 1,3-dipolar cycloaddition reaction and their functionalization leads to derivatives with potential biological activities.

Highlights

The isoxazoles derivatives are a family of interesting compounds due to their biological activities
Some of these are used as muscle relaxants [1] and for the treatment of hypercholesteremia, arteriosclerosis, and hyperlipidemia [2]
In previous papers we performed the synthesis of 3-glycosyl-5-substituted-2-isoxazoles by 1,3dipolar cycloaddition, where the N-oxide came from protected carbohydrate derivatives [3]

Summary

Introduction

The isoxazoles derivatives are a family of interesting compounds due to their biological activities. Some of these are used as muscle relaxants [1] and for the treatment of hypercholesteremia, arteriosclerosis, and hyperlipidemia [2].

Results

Conclusion