Synthesis of Heterocyclic Compounds Via Chalcone Derivatives and Study Activity of Some these Compounds as Pesticides (Anti-Dubas)

Abstract

In this research, we synthesized oxazine and thiazine derivatives (3-6). These derivatives of chacone compounds (1 and 2) that synthesized from 4- hydroxyacetophenone and aldehyde derivatives such as, 4-bromobenzaldehyde and 4- chlorobenzaldehyde. These derivatives of chalcone (1-2) reacted with urea to produce oxazine derivatives as 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-oxazin-2-yl] phenol (3 and 4) and thiourea to produce 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-thiazin-2-yl] phenol (5 and 6). These derivatives were characterization by spectroscopy methods such as, FTIR and 1HNMR. Some compounds (3 and 5) that synthesized tested as Pesticides (anti-dubas) through the spray method and these derivatives killed Dubas and we noted the compound 5 was more active from compound 3 because compound 5 have been S atom in his structure that bonded in active group in dubas by effect on Cholinesterase enzyme in the insect.