Synthesis of hetarylquinolines from 4-(4-hydroxy- 2-methylquinolin-3-yl)butan-2-one thiosemicarbazones

Abstract

Heterocyclic thiosemicarbazones and thiosemicarbazides, including quinoline derivatives, are polyfunctional substrates that are widely used in the development of methods for the synthesis of biologically active compounds which may be promising as medicinal agents [1–3]. Increased attention is now given to the chemistry of quinoline derivatives, in particular hetarylquinolines, i.e., compounds whose molecules consist of two heterocyclic fragments, one of which is quinoline. Compounds exhibiting anticancer, antifungal, antiviral, antibacterial, and immunomodulatory activity have been found in the series of hetarylquinolines [4–11].