Synthesis of Hafnium(IV) Polyaminoacetates.

Alexandra T Shulyak,Konstantin Yu Zhizhin,Alexander Yu Bykov,Evgeniy O Bortnikov,Nikolai T Kuznetsov,Alexey S Kubasov,Nikita A Selivanov,Andrey P Zhdanov,Alexey A Lipengolts

doi:10.3390/molecules26123725

Abstract

The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na2[Hf(NTA)2]·3H2O (1), Na[HfDTPA]·3H2O (2), [HfCDTA(H2O)2] (3), and Na[Hf2(dpta)2]·7.5H2O·0.5C2H5OH (4) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H2O)2] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.

Highlights

Radiological research methods are the main methods for diagnosing malignant neoplasms
Iodine has a sufficiently large radius, which contributes to a high absorption coefficient of X-ray radiation [10]; in [11], water-soluble complexes containing hafnium(IV) were obtained, which proved to be better as a contrast agent in comparison with the preparation Iopromide©
It is known that the hydrolysis of hafnium cations begins already at pH > 0, depending on the concentration of the metal in the solution [24,25]

Summary

Introduction

Radiological research methods are the main methods for diagnosing malignant neoplasms. Contrast agents are used [1]. Complexes of gadolinium(III) with polyaminocarboxylic acids (for example, diethylenetriamine pentaacetic acid (DTPA)) (Figure 1) are successfully used for magnetic resonance imaging [2,3,4]. Only organoiodine compounds are mainly used for computed tomography [7,8,9], and attempts to use gadolinium preparations for this method were unsuccessful [9]. Iodine has a sufficiently large radius, which contributes to a high absorption coefficient of X-ray radiation [10]; in [11], water-soluble complexes containing hafnium(IV) were obtained, which proved to be better as a contrast agent in comparison with the preparation Iopromide©

Objectives

Methods

Results

Conclusion