Synthesis of guanidines via the I2 mediated desulfurization of N,N′-di-Boc-thiourea

Hao-Jie Rong,Cui-Feng Yang,Tao Chen,Yong-Qiang Wang,Bin-Ke Ning

doi:10.1016/j.tetlet.2019.150970

Synthesis of guanidines via the I2 mediated desulfurization of N,N′-di-Boc-thiourea

Hao-Jie Rong, Cui-Feng Yang + Show 3 more

https://doi.org/10.1016/j.tetlet.2019.150970

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Journal: Tetrahedron Letters	Publication Date: Jul 23, 2019
Citations: 10

Affiliation: Northwest University

#Synthesis Of Guanidines #Primary Amines + Show 1 more

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Abstract

The I2 mediated desulfurization of N,N′-di-Boc-thiourea was developed. Various primary amines, including sterically and electronically deactivated primary amines, were transformed into the corresponding bis-Boc protected guanidines under mild conditions.

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