Synthesis of Graphene Oxide Modified Poly(sebacic anhydride) Hybrid Materials for Controlled Release Applications

Abstract

Hybrid materials of polysebacic anhydride (PSA) with graphene oxide (GO) were successfully synthesized for drug controlled release applications. Lomefloxacin (LMF) was chosen as a model antibacterial drug to investigate its release properties. The LMF-contained pills of the GO/PSA and PLA blend were made by preheating and compressing in a mold, and then controlled release behavior of these pills was investigated. The in vitro drug release indicated that the release rate was depended on the GO content in hybrid materials. Within a month, these hybrids exhibited ideal zero-order release behavior with highly effective drug release amount. The cumulative release equations was Y4% = 2.75567X + 4.70247 for 4%GO/PSA/PLA/LMF pills, with a high correlation coefficient of 99.734% and effective drug release amount of 85.9%. This suggested that GO/PSA hybrids were promising new systems for biological and medical applications.