Abstract
In this study, we introduce a simple and green method for synthesis of gold nanoparticles (AuNPs) using microbial glycolipid mannosylerythritol lipid (MEL) produced from Ustilago maydis CGMCC 5.203 and to evaluate their biomedical activities. MEL was found 10.3 g/L using sunflower oil. The formation of MEL-AuNPs was verified using UV–visible spectrum, XRD, TEM, FTIR, SEM, and EDX. In the biomedical examinations, MEL-AuNPs demonstrated potential cytotoxicity against HepG2 cells, and IC50 values were found to be 100 and 75 µg/mL for 24 h and 48 h of exposure, respectively, which indicates its good performance against cancer cells. The IC50 value of MEL-AuNPs was found to be 115 and 124 µg/mL for DPPH and ABTS scavenging activities, respectively. The biosynthesized MEL-AuNPs significantly inhibited cell growth of pathogenic Gram-positive and Gram-negative bacteria. These findings indicated that MEL plays a crucial role in the rapid biofabrication method of metallic NPs possessed the potential of biomedical activities.
Highlights
In recent years, gold nanoparticles (AuNPs) have gained considerable attention due to their wide range of potential applications including anticancer (Rajeshkumar 2016) antimicrobial (Dorosti and Jamshidi 2016), antioxidants (Muthuvel et al 2014), and agriculture (Mahakham et al 2016)
Considerable attention has been paid to the green synthesis of nanoparticles through biosurfactants and biological substances, because of hazardous and toxic by-products are usually paired with chemical methods (Kasture et al 2008; Kumar et al 2010)
Mannosylerythritol lipids (MELs, Fig. 1c) are microbial glycolipid biosurfactants comprised of 4-O-β-dmannopyranosyl-d-erythritol and a fatty acid or an acetyl group acting as hydrophilic and hydrophilic moieties, respectively Kitamoto (2008)
Summary
Gold nanoparticles (AuNPs) have gained considerable attention due to their wide range of potential applications including anticancer (Rajeshkumar 2016) antimicrobial (Dorosti and Jamshidi 2016), antioxidants (Muthuvel et al 2014), and agriculture (Mahakham et al 2016). They have widely used in applications of the biolabelling, photothermal therapy, tissue/tumor imaging, biosensors, drug delivery and detection of the pathogens (Ganesh Kumar et al 2011). The potential bioactivities of MEL-AuNPs in antibacterial, antioxidant, and cancer cell cytotoxicity were evaluated
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