Abstract
Photothermal therapy is considered as an alternative to conventional cancer therapy methods, which is a mild practice compared to chemotherapy, radiotherapy, and surgery. The purpose of this study is to synthesize a photosensitizing agent having strong near-infrared (NIR) (˜808 nm) absorption, low cytotoxicity, magnetic properties, and excellent stability. For this purpose, graphene oxide-iron (II,III) oxide-polyaniline (GO-Fe3O4-PANI) was synthesized for the first time towards photothermal application and characterized by UV–vis, FTIR, XRD, TEM, and VSM analyses. The photothermal performance of the nanocomposite was investigated at various concentrations (0.1, 0.05, 0.025 mg/mL) under 1, 1.5, and 2.5 W/cm2 laser power density values. Photothermal conversion efficiency values of the samples were calculated by time constant method and a maximum of 65.80% efficiency was obtained (0.1 g/mL concentration at 1.5 W/cm2 for 5 min). This novel nanocomposite demonstrated superior results among PANI based photosensitizing agents.
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