Abstract
Polymers based on lactide and glycolide are widely used in medicine and pharmaceutics. Glycolide is one of initial monomer for lactide-glycolide copolymers obtainment and its purity has a great significance for production of such polymers with high molecular weight. This research is devoted to the synthesis of glycolide by depolymerization of glycolic acid oligomers modified by polyhydric alcohols in the presence of magnesium, zinc and tin (IV) oxides as the catalysts. Modification of glycolic acid oligomers by polyhydric alcohols allow controlling their molecular weight and decreasing crystallinity degree that affect the oligomers solubility in dimethyl sulfoxide and the yield and purity of target glycolide. Modification of glycolic acid oligomers by polyhydric alcohols results in increasing the yield by 5-10 % and achieving the purity of monomers by 99.0 % in comparison with synthesis from unmodified oligomers. To determine glycolide content in samples, gas chromatography using acetonitrile and hexafluoroisopropanol as solvents was carried out.
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