Abstract
Our ring switching strategy for synthesis of compounds with structural features consistent with activity at glutamate receptors has been modified to prepare L-alanine derivative substituted at the β-carbon atom with six-membered heteroaromatic rings. The pyrimidinone ( 11, R = R 1 = R 2 = H ) has been shown to be a glutamate agonist and the compound ( 13) to be an antagonist.
Published Version
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