Synthesis of ginger derived nanocarriers (GDNC) and study of in vitro release of 5-amino salicylic acid (5-ASA) as an anti inflammatory drug

Abstract

In the present study ginger derived nanocarriers were prepared, characterized and used for the controlled release of an anti-inflammatory drug 5-ASA (5-amino salicylic acid). The mechanism of drug targeting was based on the release of 5-ASA drug molecules from the ginger derived nanocarriers having 62.24% drug loading capacity and 80.55% drug entrapment efficiency, and undergoing swelling in aqueous release medium. The present study considered the ginger not only for preparing nanocarriers but also as a medicine with anti-inflammatory, anti-oxidative and anti-bacterial actions. The nanocarriers obtained as a fine powder were characterized by different techniques such as Fourier-Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) analysis, Differential Scanning Calorimetry (DSC), Thermal Gravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS) based measurements of size and zeta potential, respectively. The particle size was found to be within 50 nm–100 nm range whereas the zeta potential was −29.2 mV at pH 6.9. The effect of various factors like drug loading and entrapment efficiency, pH, and nature of the release medium was observed on the release profiles of 5-amino salicylic acid. The in vitro experiments were also conducted to check the stability of carriers in different pH environments and simulated biofluids.