Synthesis of functionalized quinolines from the cascade reactions of N-aryl amidines with two CF3-ynones via C–H/N–H/C–N/C–C bond cleavage

Abstract

We present a novel synthesis of CF3- and alkynyl-substituted quinoline derivatives based on Rh(iii)-catalyzed cascade reactions of N-aryl amidines with two CF3-ynones. Then, some products are transformed into polycyclic CF3-benzo[k]phenanthridines through an intramolecular annulation reaction.