Abstract
Membrane conductance changes evoked by bath-applied GABA (2–640 μM) and some related agonists were recorded intracellularly in Xenops oocytes previously injected with chick brain mRNA. Muscimol and 3-aminopropanesulphanate were ≈4 and 0.25 times as potent as GABA in producing a conductance increase. GABA responses were antagonized by bicuculline (10 μM) or picrotoxinin (10–100 μM) but were clearly enhanced by the benzodiazepine (BZ) receptor ligand chlorazepate or by pentobarbiton. We conclude that an appropriate fraction of brain mRNA was capable of directing the synthesis and correct insertion of functional GABA-BZ-barbiturate/receptor complexes in the oocyte membrane.
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