Synthesis of fully substituted iminolactones via a three-component condensation of isocyanides and acetylenic esters with 2-bromo-1-(4-bromophenyl)ethanone

Abstract

A novel three-component condensation reaction between an isocyanide, an electron-deficient acetylenic ester, and 2-bromo-1-(4-bromophenyl)‐ethanone efficiently provides fully substituted iminolactones in a one-pot condensation reaction without any activation or modification in high yields.