Abstract

Abstract:: Four eugenol metabolites were concisely synthesized and their structures were confirmed by 1H-NMR, 13C-NMR and high-resolution mass (HR-MS). Among them, the synthesis of eugenol-β-Dglucuronide (3) and eugenol sulfate (4) was reported for the first time. The successful synthesis of the four eugenol metabolites provides a material basis for further metabolic study of prodrug aspirin eugenol ester (AEE).

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