Abstract
[ 18 F ]fluoroiodomethane was labeled via nucleophilic substitution of diiodomethane with [ 18 F ]fluoride, and labeling conditions were optimized. The optimized labeling yield was 40±8% (decay-corrected). The synthesis and purification of [ 18 F ]fluoroiodomethane took 15 min. The reactions of [ 18 F ]fluoroiodomethane with amine, carboxylic acid, thiol and phenoxide groups produced fluoromethylated derivatives with various yields (12–95%). The results indicated that [ 18 F ]fluoroiodomethane is a valuable synthetic precursor for the introduction of an [ 18 F ]fluoromethyl group into radiopharmaceuticals.
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