Abstract
A general route for synthesis of 6- O -alkyl-2∝deoxyguanosine nucleosides is described. The key step is conversion of the 6- O -TPS derivative 2 to the 6-trimethylamino compound 3 . The trimethylamino group is readily displaced by alcohols in the presence of DBU. Using this route the 6- O -methyl, ethyl and n-butyl 2∝-deoxyguanosine derivatives 5a-c have been prepared in excellent overall yields.
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