Abstract
The introduction of one or two fluorine atoms into a carbon-carbon double bond often brings about profound changes of physical, chemical and/or biological properties of the target molecule. Fluorinated alkenes are a class of important compounds and widely used in medicinal chemistry and materials science. Julia and Julia-Kocienski reactions could be used in the synthesis of fluorinated alkenes by employing α-fluorinated sulfones. In this review, the synthesis of fluorinated alkenes through Julia and Julia-Kocienski reactions are summarized, and the contents are categorized by target molecules and sulfone reagents. The difference between the reaction conditions for monofluoromethyl sulfones and difluoromethyl sulfones reflects the unique effect of fluorine substituents.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
