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Abstract
Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as six‐membered rings such as; N,Nʼ‐disubstituted‐thiobarbituric acid, 3‐thioxo‐1,2,4‐triazino[5,6‐b]indole, 3‐sulfanilamido‐1,2,4‐triazino[5,6‐b]indole and 2‐trifluoromethyl‐4‐imino‐6‐(sulfamido)1,3,5‐triazino [3,2‐a]indole derivatives (2‐13) have been synthetically derived from the interaction of sulfa drugs with fluorine organic compounds (aldehydes, ketones, anhydride) followed by ring closure reactions. Structures of the targets have been established from their elemental and spectral data. Compounds 3, 6, 10 and 13 could be used as photochemical probe agents in compared with nystatin and nalidixic acid for inhibition of vitiligo diseases.
Highlights
In recent years, human pathogenic microorganisms have developed resistance in response to the indiscriminate use of commercial antimicrobial drugs commonly employed in the treatment of infectious diseases[1]
The undesirable side effect of certain antibiotics and the emergence previously uncommon infections, has forced scientists to look for new antimicrobial substances from various fluorine-heterocyclic systems such as photochemical probe agents
Photodynamic therapy (PDT) is a cancer treatment leading to the selective destruction of malignancies by visible light in the presence of a photosensitizer and oxygen via molecular oxygen into excited triplet state
Summary
Human pathogenic microorganisms have developed resistance in response to the indiscriminate use of commercial antimicrobial drugs commonly employed in the treatment of infectious diseases[1]. A mixture of sulfa drugs, as sulfanilamide, sulfa isoxazole and or sulfapyridine (0.01 mol) in DMF (20 mL) and phenylisothiocyanate (0.01 mol) in dioxan (20 mL) was warmed for 1 h, cooled poured onto ice. The solid obtained was filtered off and crystallized to give the compounds 1(a-c) (Table 1). A mixture of compound 2c (0.01 mol) and hexafluoroacetic anhydride (0.012 mol) in THF (20 mL) was warmed under reflux for 2 h and cooled.
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