Abstract

The synthesis of fluorinated octahydro-2 H -chromene was carried out using the Prins reaction between the monoterpenoid (–)-isopulegol and carbonyl compounds in the presence of the BF 3 ·Et 2 O/H 2 O,system, which acts as both an acid catalyst and a fluorine source. The use of the readily available and easy-to-use BF 3 ·OEt 2 reagent makes this method of obtaining fluorine derivatives simple and practical. Authors: Irina V. Il'ina, Oksana S. Patrusheva, Dina V. Korchagina, Konstantin P. Volcho*, Nariman F. Salakhutdinov

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