Abstract
This study demonstrates a novel method for synthesizing rare heterocyclic compounds, namely, cyclic isoureas using alkenoic ureas via cobalt-catalyzed metal-catalyzed hydrogen atom transfer/radical polar crossover (MHAT/RPC). This method successfully produces five-membered rings along with the rare six- and seven-membered cyclic isoureas. Density functional theory (DFT) calculations were performed to elucidate the reaction mechanism focusing on cyclization.
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