Synthesis of five‐ring‐fused azepinone derivatives from bis‐isatins via sequential 6π‐electrocyclic ring closure, ring expansion, and dehydrogenation process

Abstract

AbstractFive‐ring‐fused azepinone derivatives were synthesized serendipitously from bis‐isatins via sequential 6π‐electrocyclic ring closure, ring expansion, and dehydrogenation process in moderate yields (34%–47%). The reaction was carried out in diphenyl ether at 230 °C for 4–12 h under O2balloon atmosphere.