Synthesis of Ethyl 4-(4-Nitrophenoxy) Picolinate

Abstract

Ethyl 4-(4-nitrophenoxy) picolinate 4 is an important intermediate for the synthesis of many biologically active compounds. The compound ethyl 4-(4-nitrophenoxy) picolinate was obtained by three simple steps to synthesis from 2-picoliniacid. In this paper, three novel chloropicolinoyl chloride derivatives were prepared. The structure was confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the target product was 78.57%.