Abstract
Synthesis of the ester-linked glucoside conjugate of paclitaxel, 7-propionylpaclitaxel 3″- O-β-d-glucopyranoside, was carried out by chemoenzymatic procedures. The encapsulation efficiency (EE) values for hybrid-bio-nanocapsules of the compound were much improved in comparison with those of paclitaxel. The hybrid-bio-nanocapsules targeted with trastuzumab, which contained 7-propionylpaclitaxel 3″- O-β-d-glucopyranoside, showed high anticancer activity.
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