Abstract
AbstractThe synthesis of (±)‐epi‐jungianol was successfully carried out by the gold(I)‐catalyzed propargyl Claisen rearrangement/hydroarylation cascade reaction of suitably substituted propargyl vinyl ethers as the key step to form the indane skeleton. Two routes were compared, which involved substrates with a different degree of substitution on the vinyl moiety. The one based on a propargyl vinyl ether bearing an unsubstituted vinyl moiety, despite entailing two additional steps, provided the final compound in a higher overall yield. A method for the preparation of acid sensitive propargyl vinyl ethers with an α‐alkyl‐substituted vinyl moiety and their reactivity under gold catalysis is also reported.
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