Abstract
The stereocontrolled formation of eight- and nine-membered lactones by Cu(I)Cl/2,2’-bipyridine-catalyzed atom transfer cyclization of enantiomerically pure oxygen-substituted ω-alkenyl di- and trichloroacetates is described. The lactones are formed exclusively via the endo-cyclization mode and generally show a characteristic cis-relationship between the C-5 and C-6 substituents due to a highly stereoselective ring closure and chlorine transfer.
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