Synthesis of enantiomerically pure 9[(1′ R,2′ R,3′ S)-bis(hydroxymethyl)thietan-1′-yl]adenine, 3′-thio analog of oxetanocin A

Abstract

The enantiomerically pure synthesis of 9-[(1′ R,2′ R,3′ S)-bis(hydroxymethyl)thietan-1′-yl]adenine 2, 3′-thio analog of oxetanocin A, was achieved via coupling with sulfoxide 17 and 6-chloropurine in the presence of TMSOTf and Et 3N under the Pummerer reaction conditions.