Abstract

Enantiomerically pure α-alkyl-ω-aminocarboxylic acids 5, 6 and the corresponding α-alkyllactams 7 are synthesized starting from lactams 1 by ring transformation with a chiral aminoalcohol 2, asymmetric α-alkylation of the resulting 2-(ω-aminoalkyl)-oxazolines 3 and final hydrolysis.

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