Abstract
AbstractSynthesis of DL‐2‐(p‐hydroxyphenyl)glycine by the ammonolysis of p‐hydroxymandelic acid obtained by the condensation of phenol and glyoxylic acid was investigated. Different procedures for the isolation of p‐hydroxymandelic acid from the product mixture after the condensation step were considered. The ammonolysis of the mandelic acid could be suitably carried out at 115°C using a 10:1 mole ratio of ammonia to p‐hydroxymandelic acid in the presence of ammonium chloride. A yield of glycine as high as 92% could be obtained when an overall conversion of the mandelic acid was about 80 %. The reaction was found to be first order with respect to the mandelic acid up to a reaction period of 6 h.
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