Abstract
Two different α-D-mannopyranosides having aminated heteroaliphatic ( 2) and p-isothiocyanatophenylated ( 10) aglycones were prepared and used as key precursors for the conjugation to a 3,5-diaminobenzoic acid core ( 3) using thiourea and amide coupling chemistry. The resulting divalent mannopyranoside clusters 6, 7, and 12 were shown to inhibit binding of Concanavalin A and pea lectins to yeast mannan more efficiently than their corresponding monosaccharide derivatives.
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