Synthesis of disaccharides for the study of human blood antibodies capable of recognizing the inner Glcβ1-3GalNAc disaccharide fragment of bacterial polysaccharides

Galina V Pazynina,Svetlana V Tsygankova,Polina S Obukhova,Nadezhda V Shilova,Alexander S Paramonov,Alexander O Chizhov,Yuriy A Knirel,Nicolai V Bovin

doi:10.1016/j.mencom.2023.06.011

Synthesis of disaccharides for the study of human blood antibodies capable of recognizing the inner Glcβ1-3GalNAc disaccharide fragment of bacterial polysaccharides

Galina V Pazynina, Svetlana V Tsygankova + Show 6 more

https://doi.org/10.1016/j.mencom.2023.06.011

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Journal: Mendeleev Communications

Publication Date: Jul 1, 2023

Affiliation: Institute of Bioorganic Chemistry, N.D. Zelinsky Institute of Organic Chemistry

#Inhibition Assays #Human Antibodies + Show 8 more

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Abstract

Disaccharides with the terminal Glcβ1-3 motif were synthesized as probes for studying human blood antibodies. An antibody isolated using Glcβ1-3GalNAcα–Sepharose was found to bind the inner part of the polysaccharide [–4GlcA6LThr3Acβ1-6Galβ1-6Glcβ1-3GalNAc6Acβ1–]n as evidenced by the use of a printed glycan array and inhibition assays.

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