SYNTHESIS OF DIFFERENT OXADIAZOLES: A CRITICAL REVIEW

Abstract

Oxadiazoles are an interesting class of five-membered heterocyclic compounds containing two atoms of nitrogen and one atom of oxygen [1]. Their lipophilicity is a key property that affects a drug's ability to arrive at the focus by trans-membrane diffusion, and their action against benign tuberculosis by inhibiting lipid biosynthesis is highly promising. This review was emphasized on the synthesis of different oxadiazoles with scheme. For the same, a detailed literature survey was done. Antimicrobial, anticonvulsant, antiepileptic, antiallergic, anticancer, anti-tubercular, and insecticidal actions are just few of the many biological effects shown by 1,3,4-oxadiazole derivatives. The Green Chemistry Program was launched in 1991 by the Environmental Protection Agency and the National Science Foundation. A joint effort between J.C. To lessen or do away with chemical dangers and environmental degradation, Warner has developed twelve key principles of green chemistry. It is necessary to create new medications for the treatment of pain and inflammation without the frequent adverse effects of NSAIDs (gas, bloating, heartburn, ulcer, stomach discomfort). In conclusion, the oxadiazole derivatives are more effective than nonsteroidal anti-inflammatory drugs (NSAIDs) in treating pain and inflammation-induced arthritis. The compounds of 1,3,4-oxadiazole were synthesized using microwave assistance technique.