Abstract
Synthesis of 6-subsituted-2,10-dibromodibenzo[d,g][1,3,6,2]dioxathiaphosphocin 6-sulfides (3a-1) has been accomplished in a two-step process. Reaction of 5,5′-dibromo-2,2′-dihydroxydiphenyl sulfide 1 and thiophosphoryl chloride in equimolar quantities in the presence of triethylamine as a base and DMAP as a catalyst in anhydrous toluene afforded the intermediate 6-chloro-2,10-dibromodibenzo[d,g][1,3,6,2]dioxathiaphosphocin 6-sulfide 2. Subsequent reaction of the monochloride 2 with sodium phenoxides/thiophenoxides afforded the title compounds. All the compounds showed moderate activity against bacteria and fungi.
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