Abstract
AbstractApplication of nanotechnology and nanomaterials in cancer therapeutics has attracted much attention in recent years. Here, we prepared diamond‐shaped mesoporous TiO2 nanobricks (MTNs for short) via a facile and reproducible synthetic strategy. The obtained MTNs possess excellent biocompatibility, drug loading capability and pH‐responsive property through covalent conjugation to succinmidyl glutarate (PEG). These features enable the drug‐loaded PEG‐MTNs to be applied for cancer therapy. The confocal laser scanning microscopy studies show that the MTNs could be efficiently internalized by cancer cells and the loaded doxorubicin (DOX) in the MTNs could be successfully released in acidic intracellular environment. Meanwhile, the mice treated with drug‐loaded PEG‐MTNs exhibits the better tumor inhibition than those with free DOX. These data indicate the effectivity and significance of the MTNs in the cancer therapy.
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